The implication of adenosine receptor expression in prediction of methotrexate clinical response in Egyptian rheumatoid arthritis patients

Abstract Background Adenosine signaling is now an accepted explanation for the therapeutic mechanism of Methotrexate (MTX) in rheumatoid arthritis (RA). receptors categorized into four subclasses: adenosine A1 receptor (ADORA1), 2a (ADORA2a), 2b (ADORA2B), and 3 (ADORA3). Our aim to check mRNA expression two receptors; ADORA2a ADORA3 whole blood cell RA patients its relation prediction MTX clinical response Egyptian patients. Results There was significant correlation between both gene as compared with healthy controls. The increased good moderate groups no group. genes before after treatment. Matrix metalloproteinase-3 (MMP3) concentration significantly decreased treatment comparison non-responder Conclusion inflammatory responses which demonstrated by DAS28 suppression MMP3 were regulated ADORA3. Their level can predict their agonists may offer a novel effective option